International Society of Biomechanics
Gold sponsor

PhD position: Computer Optimization of Scaffolds for Bone Regeneration

Category
PhD position
Posted
31 Jul 2019
Modified
31 Jul 2019
City
Berlin, n/a
Country
Deutschland
Organisation
Julius Wolff Institute, Charité – Universitätsmedizin Berlin
A PhD position is available within the Computational Mechanobiology Group at the Julius Wolff Institute (Charite Medical School in Berlin)
on the topic of computational optimization of scaffolds to promote bone regeneration within large bone defects.

Background
Although bone has the fascinating ability to self-regenerate after injury, large bone defects often lead to delayed or non-unions. The
treatment of these conditions remains a clinical challenge for which scaffold-based strategies appear as a promising approach. In this
approach, 3D open porous structures are implanted in the bone defect with the aim to support bone regeneration. Although, preliminary
pre-and clinical data show encouraging results, there is still a need to optimize these scaffolds to ensure successful healing. The growth
of new bone within the scaffold is influenced by many factors, such as the scaffold architecture, material properties, patient health
condition, etc. The aim of this project is to investigate the potential optimization of scaffolds to promote bone regeneration within large
bone defects.

Tasks
You will develop computer models to simulate the bone healing process and the interaction between mechanical signals (strains) within
the healing region and biological processes (e.g. cellular migration, matrix deposition, etc.) taking place. You will simulate the interaction
of the bone regeneration process with scaffold-support structures and develop algorithms for the computer optimization of the scaffold
design to promote the bone healing process. You will be able to compare model predictions with experimental data from animal studies
(e.g. histology, microCT) and to have access to patient data. The project is part of a research collaboration between several Institutes
on the topic of “Personalised Bone Defect Treatment” (Funded by the BMBF).

Your profile
- A degree in Mechanical Engineering/Computer Science/Mathematical Biology or a related discipline
- Knowledge of Finite Element Modelling will be advantageous
- Experience in Programming is required (e.g. C/C++, Matlab)
- High motivation and strong interest in research

What we provide
This position is available for a period of three years. Salary will be commensurate with experience. You will work in a friendly team
and in a unique research environment. As a PhD student you will be associated to the Berlin-Brandenburg School of Regenerative
Therapies (www.bsrt.de) and benefit from the interaction with international students. Starting date: 1st October, 2019.

Apply
Interested candidates should send a CV, a cover letter and two references that could be contacted. Please email the application to
Prof. Checa via email at: sara.checa@charite.de